The Callisto Protocol is a 2022 survival horror video game developed by Striking Distance Studios and published by Krafton. It is directed by Dead Space series creator Glen Schofield and is considered a spiritual successor to the series.

The game’s story follows Jacob Lee (Josh Duhamel), a starship captain who survives a crash landing on the Jovian moon Callisto, only to be captured and incarcerated against his will in a high-security prison. He is subsequently forced to fight for survival when a mysterious illness sweeps the prison, and gradually learns the dark secrets of his captors. Gameplay has players exploring a series of levels, gathering resources and collecting data logs while fighting off infected prisoners.

Development of the game began with the formation of Striking Distance Studios in June 2019. Originally developed as a game set in the PUBG: Battlegrounds universe, it later evolved into an original intellectual property.

The game was released for PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S on December 2, 2022. It received mixed reviews and failed to meet the sales expectations of Krafton.

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